Skeletal muscle insulin resistance is the root cause of reactive elevated insulin levels. Muscle utilizes fatty acids for fuel, rather than glycogen converted to sugar. We only have several thousand calories stored in muscle as glycogen, but many hundreds of thousands potentially stored as fatty acids in adipose tissue, both white and brown fat under skin and around internal organs. This adaptive change probably arose several hundred thousand years ago, to survive famines and ice ages. It is the famine response triggered by mineral depleted soils, high sugar and carbohydrate diets, and stress hormonal responses.
Obese individuals have not only elevated insulin levels fasting and after meals, but counter-insulin hormones, glucagon and cortisol. The pancreas makes insulin but also glucagon, that promotes liver conversion to sugar, especially overnight. Cortisol pushes sugar upward countering surging insulin, and comes from the adrenals, showing a mild stress hormone response to swinging blood sugar levels.
The solution to Obesity and Diabetes is dietary, metabolic, specific kinds of exercise. Paleo and Ketogenic diets lower insulin stimulation, with low glycemic index dietary foods. Supplements that lower insulin resistance in muscles and other target organs to a lesser extent, lowers insulin output. Special supplements lower Glucagon and Cortisol, counter-insulin hormones, and thus lower sugar production. Excess glucose production is converted to fatty acids, that link on glycerol to make triglyceride or fat, that is exported from the liver to adipose tissues.
Supplements that reverse type 2, or insulin resistant hypothyroidism can raise metabolic rate, suppressed by elevation of Reverse Thyroid Hormone RT3, that can be lab evaluated. Core temperature will return to normal when Free RT3 levels are reduced. It can be monitored with an alcohol Geratherm or two digit Electronic oral thermometer, in the AM, before getting up, as muscle twitches will produce some heat to core temperature. The best exercise is non-traumatic vibration platform exercise with resistance bands or small hand weights to boost metabolic activity and fat burning actions, release NO nitric oxide, and raise GH Growth Hormone levels.
Stay well with wise natural care of functional metabolic medicine
Dr. Bill Deagle, MD, AAEM, ACAM, A4M
A third type of diabetes has been identified by researchers. Type 3c diabetes may be mistaken for Type 2 diabetes, causing delay of proper treatment.
Researchers from the University of Surrey found Type 3c diabetes to be more common in adults than Type 1 diabetes. Moreover they found that those with Type 3c were twice as likely to have poor blood sugar control than those with Type 2 diabetes.
They believe, discussed below, that the diabetes occurs years after injury to the pancreas, the organ that produces insulin. So a person with Type 3c diabetes will most likely need insulin rather than an oral medication that treats insulin resistance
Study author, Andrew McGovern, writes: …our latest study has revealed that most cases of type 3c diabetes are being wrongly diagnosed as type 2 diabetes. Only 3% of the people in our sample – of more than 2m – were correctly identified as having type 3c diabetes.
So if many Type 2 diabetics fail to maintain control with their oral medications that address insulin resistance, they may actually have Type 3c and need insulin instead as low insulin is the cause of their diabetes. Identifying this early will hopefully prevent some of the complications that occur with long term diabetes.
What is diabetes?
Diabetes is a disease in which the body doesn’t utilize and metabolize sugar properly. When we consume food, it’s broken down into proteins, nutrients, fats, water, and sugar. These components are necessary for cell growth and function. They get absorbed in the small intestine and make it to the blood stream. In order for a cell to utilize sugar, it needs the hormone insulin to help guide it in. It’s similar to a key that fits in the keyhole of the “door” of the cell, opening it up so sugar can enter. Insulin is produced in the pancreas, an organ that receives signals when one eats to release insulin in preparation of the sugar load coming down the pike
So I imagine our mouth like a waiting room, the blood stream like a hallway, and the cells of the body the rooms along the hallway. Insulin is the key to open the cells’ “doors” allowing sugar to enter. If the sugar does not get in, it stays in the bloodstream “hallway” and doesn’t feed the cell.
Weight loss occurs, and individuals may become more thirsty as the sugar in the blood makes it fairly osmotic, something the body wants to neutralize, reduce. The kidneys are going to want dump the excess sugar, so to do so, one would urinate more, again causing thirst. So when a diabetic loses weight, urinates more frequently and becomes thirsty, you now understand why.
Type I Diabetes, previously called insulin dependent or Juvenile diabetes, occurs when the pancreas doesn’t produce insulin, possibly from the immune system destroying the cells that produce the hormone. When this occurs there is rapid weight loss and death could occur if the cells don’t get the sugar they need. Insulin has to be administered regularly.
Type II Diabetes, previously called non-insulin dependent or adult-onset diabetes, occurs in those who began with a fully functioning pancreas but as they age the pancreas produces less insulin, called insulin deficiency, or the insulin produced meets resistance. This is the fastest growing type of diabetes in both children and adults.
Type IIIc diabetes may occur in individuals who suffered damage to their pancreas. Inflammation/infection of the pancreas (pancreatitis), a pancreatic tumor, or surgery affecting the pancreas may destroy the beta cells that produce insulin.
Cardiovascular disease – Sugar is sticky, so it can easily add to atherosclerotic plaques.
Blindness – high sugar content draws in water to neutralize and small blood vessels in the eye can only take so much fluid before they burst. Moreover, high blood sugar weakens blood vessels.
Kidney disease – the kidneys work overtime to eliminate the excess sugar. Moreover, sugar laden blood isn’t the healthiest when they themselves need nourishment.
Infections – pathogens love sugar. Its food for them. Moreover blood laden with sugar doesn’t allow immune cells to work in the most opportune environment.
Neuropathy – nerves don’t receive adequate blood supply due to the diabetes-damaged blood flow and vessels, hence they become dull or hypersensitive causing diabetics to have numbness or pain.
Dementia – as with the heart and other organs, the brain needs healthy blood and flow. Diabetes has been found to increase risk of Alzheimer’s as well.
Insulin resistance, if using our hallway and door analogy, is as if someone is pushing against the door the insulin is trying to unlock. As we know, those with obesity are at higher risk for diabetes, hence fat can increase insulin resistance. It’s also been associated with an increase in heart disease.
If your fasting blood sugar (glucose) is greater than 126 mg/dl, or your non fasting blood sugar is greater than 200 mg/dl, you may be considered diabetic. Pre-diabetes occurs when the fasting blood sugar is between 100 and 125 mg/dl. If ignored, and the sugar rises, pre-diabetics may go on to develop diabetes.
1/3 of American adults are currently pre-diabetic. Experts predict 1/3 of US Adults will be diabetic by the year 2050. Although genetics plays a big role, decreasing one's sugar intake and maintaining an active lifestyle can help ward of diabetes.
Foods high in sugar and carbohydrates increase one’s risk, so a diet rich in vegetables and lean meats is preferred.
For more on the study visit here.
Daliah Wachs is a guest contributor to GCN news. Doctor Wachs is an MD, FAAFP and a Board Certified Family Physician. The Dr. Daliah Show , is nationally syndicated M-F from 11:00 am - 2:00 pm and Saturday from Noon-1:00 pm (all central times) at GCN.