Skeletal muscle insulin resistance is the root cause of reactive elevated insulin levels. Muscle utilizes fatty acids for fuel, rather than glycogen converted to sugar. We only have several thousand calories stored in muscle as glycogen, but many hundreds of thousands potentially stored as fatty acids in adipose tissue, both white and brown fat under skin and around internal organs. This adaptive change probably arose several hundred thousand years ago, to survive famines and ice ages. It is the famine response triggered by mineral depleted soils, high sugar and carbohydrate diets, and stress hormonal responses.
Obese individuals have not only elevated insulin levels fasting and after meals, but counter-insulin hormones, glucagon and cortisol. The pancreas makes insulin but also glucagon, that promotes liver conversion to sugar, especially overnight. Cortisol pushes sugar upward countering surging insulin, and comes from the adrenals, showing a mild stress hormone response to swinging blood sugar levels.
The solution to Obesity and Diabetes is dietary, metabolic, specific kinds of exercise. Paleo and Ketogenic diets lower insulin stimulation, with low glycemic index dietary foods. Supplements that lower insulin resistance in muscles and other target organs to a lesser extent, lowers insulin output. Special supplements lower Glucagon and Cortisol, counter-insulin hormones, and thus lower sugar production. Excess glucose production is converted to fatty acids, that link on glycerol to make triglyceride or fat, that is exported from the liver to adipose tissues.
Supplements that reverse type 2, or insulin resistant hypothyroidism can raise metabolic rate, suppressed by elevation of Reverse Thyroid Hormone RT3, that can be lab evaluated. Core temperature will return to normal when Free RT3 levels are reduced. It can be monitored with an alcohol Geratherm or two digit Electronic oral thermometer, in the AM, before getting up, as muscle twitches will produce some heat to core temperature. The best exercise is non-traumatic vibration platform exercise with resistance bands or small hand weights to boost metabolic activity and fat burning actions, release NO nitric oxide, and raise GH Growth Hormone levels.
Stay well with wise natural care of functional metabolic medicine
Dr. Bill Deagle, MD, AAEM, ACAM, A4M