Hypertension is the measured change in pulse and resting phase pressure in the peripheral circulation. The heart is pumping against blood vessels, that should respond to the heart. In a healthy circulatory system, blood vessels provide about three quarters of the pump action moving blood, oxygen and nutrients to peripheral tissues. All of the blood flow back to the heart results for the peristaltic wave of contraction of veins back to the right side of the heart. The right heart only pumps to the lung fields to pick up oxygen.
To lower blood pressure we must improve blood vessel secondary wave of contraction, and support mitochondrial metabolism that makes up three quarters of the muscular middle layer, responsible for flow. To lower blood viscosity is essential, reduce free radicals that make vessels stiff with oxidized plaque from fatty acids and cholesterol that has be damaged. Singlet oxygen radical, hydrogen peroxide radical, and nitroperoxide radicals must be quenched. A byproduct of inadequate methyl group transfer from folate, B12, and methyl group deficiency is homocysteine which must be reduced to prevent vessel wall injury. Cholesterol is not dangerous to the artery, but small particle HDL and VLDL3 can be swallowed by macrophages and die becoming plaque forming foam cells. They release local molecules that can cause fibrin and platelets to aggregate like tar on a shack.