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Synthetic alcohol can cause the buzz without the hangover

Written by Dr. Daliah Wachs
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A synthetic alcohol, named Alcarelle, or “Alcosynth,” has been shown to give one the same effects of alcohol without the nasty hangover the next day.

Dr. Professor Nutt, apparently has been working on this for decades, as a PhD student since the early 1980’s.  The synthetic alcohol is slated to hit the market in 5 years.

He told the Guardian:

We know where in the brain alcohol has its ‘good’ effects and ‘bad’ effects, and what particular receptors mediate that – Gaba, glutamate and other ones, such as serotonin and dopamine.

“The effects of alcohol are complicated but … you can target the parts of the brain you want to target.”

Alcohol stimulates GABA, a neurotransmitter that can reduce activity of nerve cells making one sluggish.  Alcohol also inhibits glutamate which is an excitatory neurotransmitter. But the euphoric feeling one gets may be caused by alcohol’s stimulation of dopamine.

Hence if a drink that acts as ethanol, isn’t actually alcohol, side effects such as drowsiness, stomach upset and liver disease could potentially be bypassed.

Professor Nutt has not revealed the ingredients of his concoction but some resources cite it may be a benzodiazepine derivative, although last year he denied the rumors of using the Valium-like chemicals.

What is a hangover?

It’s a constellation of symptoms that occur post-partying…..and include headache, muscle ache, nausea, anxiety, moodiness, wanting to avoid light and loud sounds, eye redness, thirst and dizziness, though some hangovers may have many more symptoms.

They could be caused by a variety of factors:

  • Dehydration – alcohol isn’t the best choice to replace lost fluids during a night of dancing, plus it causes increase in urination
  • Low blood sugar – caused by lack of good nutrition over the last 12 hours and enhanced by drinking alcohol
  • Poor sleep – let me guess, you didn’t get a good nice, cuddly, deep sleep for 9 hours once you came home
  • Irritated stomach lining – alcohol tends to do that and ticks off the pancreas as well
  • Acetaldehyde – a chemical converted from alcohol that has been postulated to make you feel nauseous and achy, either during its breakdown in the liver or after its metabolism
  • Cytokine production and release – seen in inflammatory states and can make you achy

Other theories suggesting lactic acid build up, withdrawal from drinking the night before, and congeners that are compounds that vary in alcohol types (red wine vs vodka).

So how can you cure your hangover?

Water

Hydrate people, hydrate.  Alcohol is a diuretic, which means it makes you urinate more and lose valuable fluid and salts. Water is the easiest, most tolerable, cheapest way to hydrate. Take it slow so you don’t vomit.  And not scotch and water.  Just water….

Eat something

An empty stomach is an irritable one.  While most sources say eat a “greasy breakfast,” I would recommend balanced breakfast with protein. Give the stomach acid something to chew on but make it easily digestible.  Remember the alcohol irritated your gut so you need to go easy on it. Baby steps, but healthy baby steps

Exercise

Take a short, brisk walk.  The adrenaline gets the blood pumping and can help with the headache.  The cool air outside will feel good when you inhale and some endorphins will release. This may help with your headache.

Drink some Sprite/Sports Drinks

Chinese researchers back in 2013 found Sprite to be the best hangover cure and even though we don’t have many other studies to back it up, the sweet and bubbly it provides makes your head and tummy feel better.

Sports Drinks add the salts you lost from alcohol’s diuretic features. Though many of us don’t like the taste, those who do find it a nice way to hydrate.

What is “hair of the dog?”

Originally it was a treatment to ward off rabies.  One would, after being bit by a dog, put a piece of dog hair on the wound.  A treating fire-with-fire strategy. It later was used for hangovers.  Treating a hangover with a chaser of alcohol was supposed to elevate moods and lessen the withdrawal.  To date there is not enough scientific support to recommend hair of the dog.

For next time, how do you avoid the dreaded hangover?

Want to avoid a hangover?  Here’s how:

Firstly, try to avoid getting drunk.  Set your limits and stick to it.

Secondly, drink plenty of water throughout the night and once you get home.

Finally, don’t drink on an empty stomach to “speed up the buzz.” Your empty gut will absorb alcohol quicker so eat a good nutritious meal prior to partying.

Avoid popping anti-inflammatories or Tylenol once you get home because your stomach and liver are already irritated from the alcohol and this may make matters worse. But if any of the above “cures” don’t help, you may need to use these as a last resort.

 

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Daliah Wachs is a guest contributor to GCN news, her views and opinions, medical or otherwise, if expressed, are her own. Doctor Wachs is an MD,  FAAFP and a Board Certified Family Physician.  The Dr. Daliah Show , is nationally syndicated M-F from 11:00 am - 2:00 pm and Saturday from Noon-1:00 pm (all central times) at GCN.

Last modified on %PM, %27 %831 %2019 %18:%Mar